Article
Impact of CYP2D6 Genetic Variation on Radical Cure of Plasmodium vivax Malaria.
Clinical pharmacology and therapeutics - 1 Sept 2021
Suarez-Kurtz Guilherme
Abstract excerpt
Plasmodium vivax (P. vivax) is the most widespread human malaria parasite, with 2.5 billion people at risk of infection worldwide. P. vivax forms liver hypnozoites, which trigger further symptomatic episodes (relapses) weeks or months after the initial episode. Radical cure of vivax malaria requires hypnozoitocide therapy to prevent relapses. The two US Food and Drug Administration (FDA)-approved hypnozoiticides...
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