Article
Influence of CYP2C8, CYP3A4, and CYP3A5 Host Genotypes on Early Recurrence of Plasmodium vivax.
Antimicrobial agents and chemotherapy - 23 Jun 2020
Almeida Anne C G, Puça Maria C B, Figueiredo Erick F G, Barbosa Laila R, Salazar Yanka E A R, Silva Emanuelle L, Brito Marcelo A M, Siqueira André M, Vieira José L F, Lacerda Marcus V G, Monteiro Wuelton M, Melo Gisely C
Abstract excerpt
Cytochrome P450 (CYP) enzymes are involved in the biotransformation of chloroquine (CQ), but the role of the different profiles of metabolism of this drug in relation to Plasmodium vivax recurrences has not been properly investigated. To investigate the influence of the CYP genotypes associated with CQ metabolism on the rates of P. vivax early recurrences, a case-control study was carried out. The cases included...
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