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Article

Association between CYP2D6 phenotype and recurrence of Plasmodium vivax infection in south Korean patients.

Malaria journal - 10 Oct 2022

Choi Sungim, Choi Heun, Park Seong Yeon, Kwak Yee Gyung, Song Je Eun, Shin So Youn, Baek Ji Hyeon, Shin Hyun-Il, Cho Shin-Hyung, Lee Sang-Eun, Kwon Jeong-Ran, Park Sookkyung, Kim Miyoung, Oh Hong Sang, Kim Yong Chan, Kim Min Jae, Yeom Joon-Sup

Abstract excerpt

BACKGROUND: Primaquine is activated by CYP2D6 in the hepatocytes. In Korea, primaquine is the only hypnozoitocidal agent used for patients with vivax malaria. Thus, patients with poor CYP2D6 activity could have an increased risk of primaquine failure and subsequent relapse. The study sought to identify the association between CYP2D6 phenotype and recurrence of malaria in Korean patients. METHODS: A total of 102...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36217154
DOI: 10.1186/s12936-022-04311-6
PMCID: PMC9552356

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