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Article

Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses.

PloS one - 1 Jan 2016

Silvino Ana Carolina Rios, Costa Gabriel Luiz, Araújo Flávia Carolina Faustino de, Ascher David Benjamin, Pires Douglas Eduardo Valente, Fontes Cor Jesus Fernandes, Carvalho Luzia Helena, Brito Cristiana Ferreira Alves de, Sousa Tais Nobrega

Abstract excerpt

Although Plasmodium vivax relapses are classically associated with hypnozoite activation, it has been proposed that a proportion of these cases are due to primaquine (PQ) treatment failure caused by polymorphisms in cytochrome P-450 2D6 (CYP2D6). Here, we present evidence that CYP2D6 polymorphisms are implicated in PQ failure, which was reinforced by findings in genetically similar parasites, and may explain a...

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Identifiers

PMID: 27467145
DOI: 10.1371/journal.pone.0160172
PMCID: PMC4965052

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