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Article

CYP2D6 activity and the risk of recurrence of Plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study.

Malaria journal - 1 Feb 2018

Brasil Larissa W, Rodrigues-Soares Fernanda, Santoro Ana B, Almeida Anne C G, Kühn Andrea, Ramasawmy Rajendranath, Lacerda Marcus V G, Monteiro Wuelton M, Suarez-Kurtz Guilherme

Abstract excerpt

BACKGROUND: CYP2D6 pathway mediates the activation of primaquine into active metabolite(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with normal, reduced, null or increased activity. It is hypothesized that Plasmodium vivax malaria patients with defective CYP2D6 function would be at increased risk for primaquine failure to prevent recurrence. The aim of this study was to investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29390987
DOI: 10.1186/s12936-017-2139-7
PMCID: PMC5795836

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