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Distinct Metabolomic and Clinical Phenotypes of Depression in Heart Failure　- Pilot Exploratory Analysis.

Circulation journal : official journal of the Japanese Circulation Society - 25 May 2026

Kinugasa Yoshiharu, Kamitani-Noguchi Hiroko, Nakamura Kensuke, Hirai Masayuki, Manba Midori, Ishiga Natsuko, Sota Takeshi, Nakayama Natsuko, Ota Tomoki, Kato Masahiko, Yamamoto Kazuhiro

Abstract excerpt

BACKGROUND: Depression is common among patients with heart failure (HF) and worsens prognosis, but its metabolic heterogeneity remains unclear. METHODS AND RESULTS: Fifty HF patients completed the Patient Health Questionnaire-9 (PHQ-9) and underwent metabolomic profiling of 163 metabolites. Depressed patients (PHQ-9 score ≥5; n=26) were stratified using k-means clustering. Spearman's correlation with false...

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PMID: 42036314
DOI: 10.1253/circj.CJ-26-0058

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