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Quantitative Metabolomics Reveals Heart Failure With Midrange Ejection Fraction as a Distinct Phenotype of Heart Failure.

The Canadian journal of cardiology - 1 Feb 2021

Zhao Hongyu, Shui Bing, Zhao Qian, Hu Zhansheng, Shu Qiang, Su Mingming, Zhang Yingjie, Ni Yan

Abstract excerpt

BACKGROUND: Heart failure with midrange ejection fraction (HFmrEF) has been recently acknowledged as a separate phenotype, but metabolomics evaluation of this subtype remains largely unexamined. METHODS: A quantitative metabolomics study on amino acids and acylcarnitines was performed to characterize different states of heart failure (HF) in 628 participants. Both multivariate orthogonal partial least squares-...

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PMID: 32795449
DOI: 10.1016/j.cjca.2020.03.024

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