Article
Enhanced clinical phenotyping by mechanistic bioprofiling in heart failure with preserved ejection fraction: insights from the MEDIA-DHF study (The Metabolic Road to Diastolic Heart Failure).
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Mar 2020
Stienen Susan, Ferreira João Pedro, Kobayashi Masatake, Preud'homme Gregoire, Dobre Daniela, Machu Jean-Loup, Duarte Kevin, Bresso Emmanuel, Devignes Marie-Dominique, López Natalia, Girerd Nicolas, Aakhus Svend, Ambrosio Giuseppe, Brunner-La Rocca Hans-Peter, Fontes-Carvalho Ricardo, Fraser Alan G, van Heerebeek Loek, Heymans Stephane, de Keulenaer Gilles, Marino Paolo, McDonald Kenneth, Mebazaa Alexandre, Papp Zoltàn, Raddino Riccardo, Tschöpe Carsten, Paulus Walter J, Zannad Faiez, Rossignol Patrick
Abstract excerpt
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome for which clear evidence of effective therapies is lacking. Understanding which factors determine this heterogeneity may be helped by better phenotyping. An unsupervised statistical approach applied to a large set of biomarkers may identify distinct HFpEF phenotypes.Methods: Relevant proteomic biomarkers were analyzed...
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