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Article

Serum ferritin and delirium risk: an integrative genomic analysis of causal inference and multi-tissue regulatory signals.

Human genomics - 25 Apr 2026

Saed Amirhossein, Akbarzadeh Mahdi, Gohari Fatemeh, Asadrouh Nafiseh, Jahromizadeh Amir Mohammad, Sabaie Hani, Zarkesh Maryam, Hedayati Mehdi, Azizi Fereidoun, Daneshpour Maryam Sadat

Abstract excerpt

BACKGROUND: Delirium is an acute neuropsychiatric syndrome characterized by disrupted attention and cognition, often triggered by systemic inflammation and physiological stress. Elevated serum ferritin is frequently observed in patients with delirium. Since ferritin couples iron handling to inflammatory signaling during acute-phase responses, it remains unclear whether genetically influenced baseline serum...

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PMID: 42035214
DOI: 10.1186/s40246-026-00972-5
PMCID: PMC13262423

Genes

APOE
CEACAM19
SLC11A2
TF

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