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Article

Linking cortical structure and delirium in the elderly: insights from cohort study and shared genetic risk analysis.

Journal of translational medicine - 12 Feb 2026

Chen Yanbo, Zheng Jiayuan, Shen Runnan, Cheng Jinping, Wang Xudong, Liang Tongzhou, Sun Yujun, Wu Jionglin, Zheng Zhenxiang, Zhou Taolue, Li Jiajie, Liu Wenzhou, Li Yong, Zeng Gang, Song Weidong

Abstract excerpt

BACKGROUND: This study aimed to assess the association between regional cortical changes measured via baseline magnetic resonance imaging (MRI) and the incidence of delirium. METHODS: Observational associations were assessed using a prospective cohort from the UK Biobank and an independent clinical cohort. The population-based study included participants aged 60 years or older who had undergone structural brain...

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Identifiers

PMID: 41680881
DOI: 10.1186/s12967-026-07841-8
PMCID: PMC12998155

Genes

CCDC25
EEF1AKMT2
LHPP
NT5C2
RGP1
TPM2

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