Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early and late RNA eQTL are driven by different genetic mechanisms.

Nature communications - 25 Apr 2026

Sakaue Saori, Raychaudhuri Soumya

Abstract excerpt

Understanding the genetic regulation of RNA abundance is essential for defining disease mechanisms. Conventional expression quantitative trait locus (eQTL) studies measure steady-state RNA and capture effects across the entire transcript lifecycle. While most eQTL likely affect transcription by altering promoter or enhancer function within the nucleus, others may act post-transcriptionally through RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Gene Expression Regulation
Share to Kidney

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Schizophrenia

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 42034632
DOI: 10.1038/s41467-026-72139-8
PMCID: PMC13319782

Genes

TUBGCP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early and late RNA eQTL are driven by different genetic mechanisms.PMID 42034632Read ↗

Early and late RNA eQTL are driven by different genetic mechanismsSemantic proximity Read ↗

Mapping the genetic regulation of long non-coding RNAs across cellular contexts advances understanding of complex brain diseasesSemantic proximity Read ↗

Brain transcriptional regulatory architecture and schizophrenia etiology converge between East Asian and European ancestral populationsSemantic proximity Read ↗

Analysis of nucleus and cytoplasm-specific RNA fractions demonstrates that a significant proportion of the genetic regulation of gene expression across the human brain occurs post-transcriptionallySemantic proximity Read ↗

Mapping genetic variants for nonsense-mediated mRNA decay regulation across human tissuesSemantic proximity Read ↗

A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders.Semantic proximity Read ↗

High cell-type specificity of eQTLs revealed by single-nucleus analyses of brain and bloodSemantic proximity Read ↗

Disentangling genetic effects on transcriptional and post-transcriptional gene regulation through integrating exon and intron expression QTLs.Semantic proximity Read ↗

Beyond Coding Variants: RNA-Level Mechanisms in Human Disease and Precision TherapeuticsSemantic proximity Read ↗

Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesisSemantic proximity Read ↗

Direct long-read RNA sequencing uncovers functional variation affecting transcript production and RNA modificationsSemantic proximity Read ↗

Direct long-read RNA sequencing uncovers functional variation affecting transcript production and RNA modificationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.