Article

Early and late RNA eQTL are driven by different genetic mechanisms

2025-02-26

Abstract excerpt

Understanding the genetic regulation of RNA abundance is essential to defining disease mechanisms. However, conventional expression quantitative loci (eQTL) studies quantify RNA molecules across the transcript lifecycle. While most eQTL likely affect transcription by altering promoter or enhancer function within the nucleus, it is also possible that they modulate any processes after transcription, including chemic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8ab45153-3191-59a2-a9dd-6e14eee2ae7b
DOI: 10.1101/2025.02.24.639351

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early and late RNA eQTL are driven by different genetic mechanismsDOI 10.1101/2025.02.24.639351Read

Early and late RNA eQTL are driven by different genetic mechanisms.Semantic proximity Read

Mapping the genetic regulation of long non-coding RNAs across cellular contexts advances understanding of complex brain diseasesSemantic proximity Read

Brain transcriptional regulatory architecture and schizophrenia etiology converge between East Asian and European ancestral populationsSemantic proximity Read

Post-transcriptional control by RNA-binding proteins links local synaptic translation to schizophrenia genetic riskSemantic proximity Read

Disentangling genetic effects on transcriptional and post-transcriptional gene regulation through integrating exon and intron expression QTLs.Semantic proximity Read

The impact of common variants on gene expression in the human brain: from RNA to protein to schizophrenia riskSemantic proximity Read

Mapping genetic variants for nonsense-mediated mRNA decay regulation across human tissuesSemantic proximity Read

Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk.Semantic proximity Read

Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesisSemantic proximity Read

Beyond Coding Variants: RNA-Level Mechanisms in Human Disease and Precision TherapeuticsSemantic proximity Read

Direct long-read RNA sequencing uncovers functional variation affecting transcript production and RNA modificationsSemantic proximity Read

Direct long-read RNA sequencing uncovers functional variation affecting transcript production and RNA modificationsSemantic proximity Read