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Article

Elucidating the mechanism by which compensatory mutations rescue an HIV-1 matrix mutant defective for gag membrane targeting and envelope glycoprotein incorporation.

Journal of molecular biology - 27 Mar 2015

Tedbury Philip R, Mercredi Peter Y, Gaines Christy R, Summers Michael F, Freed Eric O

Abstract excerpt

The matrix (MA) domain of the human immunodeficiency virus (HIV) 1 Gag is responsible for Gag targeting to the plasma membrane where virions assemble. MA also plays a role in the incorporation of the viral envelope (Env) glycoproteins and can influence particle infectivity post-maturation and post-entry. A highly basic region of MA targets Gag to the plasma membrane via specific binding to...

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Topics

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Share to gag Gene Products, Human Immunodeficiency Virus
Share to Leukemia Virus, Murine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Spectroscopy

Share to Viral Envelope Proteins

Share to Viral Matrix Proteins

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Source

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Identifiers

PMID: 25659909
DOI: 10.1016/j.jmb.2015.01.018
PMCID: PMC4844178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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