Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body.

doi:10.1128/jvi.78.3.1552-1563.2004

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Article

Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body.

Journal of virology - 1 Feb 2004

Ono Akira, Freed Eric O

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) assembly-and-release pathway begins with the targeting of the Gag precursor to the site of virus assembly. The molecular mechanism by which Gag is targeted to the appropriate subcellular location remains poorly understood. Based on the analysis of mutant Gag proteins, we and others have previously demonstrated that a highly basic patch in the matrix (MA) domain of...

Topics

Antigens, CD
Cell Membrane
Cells, Cultured
Endosomes
Gene Products, gag
HIV-1
HeLa Cells
Humans
Jurkat Cells
Macrophages
Monocytes
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organ Specificity

Phosphoproteins

Platelet Membrane Glycoproteins

Tetraspanin 30

Viral Matrix Proteins

Virion

Source

Open in PubMed Open full text

Identifiers

PMID: 14722309
DOI: 10.1128/jvi.78.3.1552-1563.2004
PMCID: PMC321403

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