Back to search

Article

‘Inflammaging’ in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohorts

2021-12-17

Abstract excerpt

<h4>Background</h4> Major Depressive Disorder (MDD) is associated with accelerated ageing trajectories including functional markers of ageing, cellular ageing and markers of poor brain health. The biological mechanisms underlying these associations remain poorly understood. Chronic inflammation is also associated with advanced ageing; however, the degree to which long-term inflammation plays a role in ageing in MD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cb4eb371-0055-5873-b046-68c59f768817
DOI
10.1101/2021.12.17.21267979
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
‘Inflammaging’ in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohortsDOI 10.1101/2021.12.17.21267979
DNA methylation signatures of C-reactive protein associations with structural neuroimaging measures and major depressive disorderSemantic proximity
Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.Semantic proximity
Separating Clinical and Subclinical Depression by Big Data Informed Structural Vulnerability Index and Its impact on Cognition: ENIGMA Dot ProductSemantic proximity
Genetic susceptibility, inflammation and specific types of depressive symptoms: evidence from the English Longitudinal Study of Ageing.Semantic proximity
Association of Inflammation with Depression and Anxiety: Evidence for Symptom-Specificity and Potential Causality from UK Biobank and NESDA CohortsSemantic proximity
<span class="word">Peripheral <span class="word">Inflammatory <span class="word">Biomarkers <span class="word">in <span class="word">First-<span class="word"><span class="changedDisabled">Episode, <span class="word">Drug-<span class="word"><span class="changedDisabled">Naïve <span class="word">Major <span class="word">Depressive <span class="word">Disorder: <span class="word">A <span class="word">Systematic <span class="word">ReviewSemantic proximity
No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageingSemantic proximity
A DNA methylation based measure outperforms circulating CRP as a marker of chronic inflammation and partly reflects the monocytic response to long‐term inflammatory exposure: A Canadian Longitudinal Study on Aging analysisSemantic proximity
Role of Inflammation in Depressive and Anxiety Disorders, Affect, and Cognition: Genetic and Non-Genetic Findings in the Lifelines Cohort StudySemantic proximity
DNA methylation and inflammation marker profiles associated with a history of depression.Semantic proximity
Role of Inflammation in Depressive and Anxiety Disorders, Affect, and Cognition: Genetic and Non-Genetic Findings in the Lifelines Cohort Study.Semantic proximity
Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK BiobankSemantic proximity
Select a neighboring publication to make it the new centre.