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Article

Brain-wide versus genome-wide vulnerability biomarkers for severe mental illnesses.

Human brain mapping - 1 Nov 2022

Kochunov Peter, Ma Yizhou, Hatch Kathryn S, Gao Si, Jahanshad Neda, Thompson Paul M, Adhikari Bhim M, Bruce Heather, Van der Vaart Andrew, Goldwaser Eric L, Sotiras Aris, Kvarta Mark D, Ma Tianzhou, Chen Shuo, Nichols Thomas E, Hong L Elliot

Abstract excerpt

Severe mental illnesses (SMI), including major depressive (MDD), bipolar (BD), and schizophrenia spectrum (SSD) disorders have multifactorial risk factors and capturing their complex etiopathophysiology in an individual remains challenging. Regional vulnerability index (RVI) was used to measure individual's brain-wide similarity to the expected SMI patterns derived from meta-analytical studies. It is analogous to...

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PMID: 36040723
DOI: 10.1002/hbm.26056
PMCID: PMC9582367

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