Article
Gene Expression Profiles Analyzed Using Integrating RNA Sequencing and Microarray Reveals Increased Inflammatory Response, Proliferation, and Osteoclastogenesis in Pigmented Villonodular Synovitis
2021-01-05
Abstract excerpt
<h4>Background: </h4> Pigmented villonodular synovitis (PVNS) is a rare condition that involves benign proliferation of the synovial tissue and is characterized by severe joint destruction and high recurrence even after surgical resection. However, poor understanding of the pathogenesis limits its effective therapy. <h4>Method: </h4> In this study, gene expression profiles of six patients with PVNS and six patient...
Topics
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- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Inflammatory mediators and NSAID effects
- interferon and immune responses
- Musculoskeletal synovial abnormalities and treatments
- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
Identifiers and source
- Literature Corpus work
- 0cc249ac-b740-564c-8b0f-9a5d8d8a76fe
- DOI
- 10.21203/rs.3.rs-138440/v1
