Article
Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes.
International immunopharmacology - 1 Apr 2021
Wu Zewen, Ma Dan, Yang Helin, Gao Jinfang, Zhang Gailian, Xu Ke, Zhang Liyun
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly affects synovial joints. During the course of RA, the synovium transforms into hyperplastic invasive tissue, leading to cartilage and bone destruction. Fibroblast-like synoviocytes (FLS) in the synovial lining develop aggressive phenotypes and produce pathogenic mediators that lead to the occurrence and progression of disease, playing...
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