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Article

BDNF insufficiency exacerbates ALS progression.

Cell reports. Medicine - 19 May 2026

Xu Yihua, He Ji, Wang Shudan, Ge Yijun, Jia Yichang, Guo Wei, Lv Chen, Yao Xinmeng, Mao Yingying, Mei Fan, Fan Dongsheng, Yuan Peng, Lu Bai

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with progressive loss of motor neurons. Insufficiency of neurotrophic factors is suspected to underlie the disease, but direct evidence remains scarce. In this study, we discover that brain-derived neurotrophic factor (BDNF) val/met mutation, which results in a decrease in BDNF secretion, reduces survival time of ALS patients in two separate...

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Identifiers

PMID: 42013845
DOI: 10.1016/j.xcrm.2026.102758
PMCID: PMC13198251

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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