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Article

FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

PLoS genetics - 1 Mar 2011

Huang Cao, Zhou Hongxia, Tong Jianbin, Chen Han, Liu Yong-Jian, Wang Dian, Wei Xiaotao, Xia Xu-Gang

Abstract excerpt

Fused in Sarcoma (FUS) proteinopathy is a feature of frontotemporal lobar dementia (FTLD), and mutation of the fus gene segregates with FTLD and amyotrophic lateral sclerosis (ALS). To study the consequences of mutation in the fus gene, we created transgenic rats expressing the human fus gene with or without mutation. Overexpression of a mutant (R521C substitution), but not normal, human FUS induced progressive...

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Identifiers

PMID: 21408206
DOI: 10.1371/journal.pgen.1002011
PMCID: PMC3048370

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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