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Article

BDNF-overexpressing human umbilical cord mesenchymal stem cell-derived motor neurons improve motor function and prolong survival in amyotrophic lateral sclerosis mice.

Neurological research - 1 Mar 2021

Wang Jie, Hu Weiwei, Feng Zehua, Feng Meijiang

Abstract excerpt

OBJECTIVE: To investigate the beneficial effect of brain-derived neurotrophic factor (BDNF) -overexpressing human umbilical cord mesenchymal stem cell (hUC-MSC)-derived motor neurons in the human Cu, Zn-superoxide dismutase1 (hSOD1)G93A amyotrophic lateral sclerosis (ALS) mice. METHODS: The BDNF gene was transfected into hUC-MSC-derived motor neurons by the lentivirus-mediated method. hSOD1G93A mice were assigned...

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PMID: 33076784
DOI: 10.1080/01616412.2020.1834775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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