Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease.

Human molecular genetics - 1 Nov 2011

Zhai Jinbin, Zhou Weiguo, Li Jian, Hayworth Christopher R, Zhang Lei, Misawa Hidemi, Klein Rudiger, Scherer Steven S, Balice-Gordon Rita J, Kalb Robert Gordon

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) are widely expressed in the vertebrate nervous system and play a central role in mature neuronal function. In vitro BDNF/TrkB signaling promotes neuronal survival and can help neurons resist toxic insults. Paradoxically, BDNF/TrkB signaling has also been shown, under certain in vitro circumstances, to render neurons...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Denervation
Share to Inclusion Bodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrases

Share to Interneurons

Share to Motor Neuron Disease

Share to Neuromuscular Junction

Share to Receptor, trkB

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 21816949
DOI: 10.1093/hmg/ddr335
PMCID: PMC3218642

Genes

BDNF
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease.PMID 21816949Read ↗

Signaling events in axons and/or dendrites render motor neurons vulnerable to mutant superoxide dismutase toxicity.Semantic proximity Read ↗

Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons.Semantic proximity Read ↗

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.Semantic proximity Read ↗

UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALSSemantic proximity Read ↗

BDNF insufficiency exacerbates ALS progression.Semantic proximity Read ↗

Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia.Semantic proximity Read ↗

Enhanced neuronal Met signalling levels in ALS mice delay disease onsetSemantic proximity Read ↗

Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunitSemantic proximity Read ↗

Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy.Semantic proximity Read ↗

The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 MiceSemantic proximity Read ↗

Running and swimming prevent the deregulation of the BDNF/TrkB neurotrophic signalling at the neuromuscular junction in mice with amyotrophic lateral sclerosis.Semantic proximity Read ↗

Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.