Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Repurposing public sarcoma multi-omics for neoantigen discovery.

Cancer immunology, immunotherapy : CII - 21 Apr 2026

Mantas Panagiotis, Krogfelt Karen A

Abstract excerpt

BACKGROUND: Soft tissue sarcomas, particularly complex karyotype sarcomas (CKS), are characterized as "immunologically cold" malignancies driven by structural instability rather than a high tumor mutational burden (TMB). Public "legacy" cohorts are a useful resource to uncover immunotherapy biomarkers. This study used the whole-exome sequencing (WES) and RNA-sequencing of CKS patients, to overcome technical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Biomarkers, Tumor
Share to Exome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Multiomics

Share to Mutation

Share to Sarcoma

Source

Open in PubMed Open full text

Identifiers

PMID: 42012689
DOI: 10.1007/s00262-026-04395-y
PMCID: PMC13100081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Repurposing public sarcoma multi-omics for neoantigen discovery.PMID 42012689Read ↗

Repurposing public sarcoma multi-omics for neoantigen discoverySemantic proximity Read ↗

Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identificationSemantic proximity Read ↗

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltrationSemantic proximity Read ↗

The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibitionSemantic proximity Read ↗

Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypesSemantic proximity Read ↗

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigensSemantic proximity Read ↗

Tumour neoantigen repertoire computational predictions in malignant peripheral nerve sheath tumours define potential targets for immunotherapySemantic proximity Read ↗

Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.Semantic proximity Read ↗

Multiomic profiling of human and canine soft-tissue sarcomas reveals extensive molecular homology across species and identifies clinically relevant subgroupsSemantic proximity Read ↗

Driver mutation landscape of acute myeloid leukemia provides insights for neoantigen-based immunotherapy.Semantic proximity Read ↗

Tumour-wide RNA splicing aberrations generate actionable public neoantigensSemantic proximity Read ↗

Transcriptomic-Based Classification Identifies Prognostic Subtypes and Therapeutic Strategies in Soft Tissue SarcomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.