Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.

Abstract excerpt

To realize the full potential of immunotherapy, it is critical to understand the drivers of tumor infiltration by immune cells. Previous studies have linked immune infiltration with tumor neoantigen levels, but the broad applicability of this concept remains unknown. Here, we find that while this observation is true across cancers characterized by recurrent mutations, it does not hold for cancers driven by...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antigens
• Share to Ataxia Telangiectasia Mutated Proteins