Article

Vulnerability to memory decline in aging – a mega-analysis of structural brain change

2025-03-28

Abstract excerpt

Brain atrophy is a key factor behind episodic memory loss in aging, but the nature and ubiquity of this relationship remains poorly understood. This study leveraged 13 longitudinal datasets, including 3,737 cognitively healthy adults (10,343 MRI scans; 13,460 memory assessments), to determine whether brain change-memory change associations are more pronounced with age and genetic risk for Alzheimer’s Disease. Both...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e9277aa-5829-563a-b52f-1b32c4a02f68
DOI: 10.1101/2025.03.27.642988

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vulnerability to memory decline in aging – a mega-analysis of structural brain changeDOI 10.1101/2025.03.27.642988Read

Regional brain aging patterns reveal disease-specific pathways of neurodegenerationSemantic proximity Read

Accelerated brain change in healthy adults is associated with genetic risk for Alzheimer’s disease and uncovers adult lifespan memory declineSemantic proximity Read

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8 <sup>th</sup> decade of lifeSemantic proximity Read

Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.Semantic proximity Read

Patterns of progressive atrophy vary with age in Alzheimer's disease patients.Semantic proximity Read

Generational gains in memory capacity and stability may account for declining dementia incidence rates in Europe and the United StatesSemantic proximity Read

Voxel-wise insights into early Alzheimer's disease pathology progression: the association with APOE and memory decline.Semantic proximity Read

Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without DementiaSemantic proximity Read

Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life.Semantic proximity Read

Alzheimer’s Disease Selectively Perturbs Age-Sensitive Brain Radiomic Features Across the Disease ContinuumSemantic proximity Read

A snapshot of brain and cognition in healthy mid-life and older adultsSemantic proximity Read

Generational gains in memory capacity and stability may account for declining dementia incidence rates in Europe and the United StatesSemantic proximity Read