Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delving Into the Depths of AGTR2: In Silico Identification of Deleterious Nonsynonymous SNPs Associated With Cardiovascular Diseases.

Human mutation - 1 Jan 2026

Waleed Iqbal Muhammad, Shahab Muhammad, Sun Xinxiao, Akter Shahina, Zheng Guojun, Shazly Gamal A, Bourhia Mohammed, Dauelbait Musaab, Yuan Qipeng

Abstract excerpt

Background and Aim: Nonsynonymous single nucleotide polymorphisms (nsSNPs) in angiotensin Type II receptor (AGTR2) have been identified as a potential cause of cardiovascular illness in humans. Identifying structurally and functionally relevant alterations in AGTR2 is critical to investigate possible therapeutic targets. Methods: A comprehensive computational pipeline was employed to evaluate deleterious nsSNPs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Diseases
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Gene Regulatory Networks

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Polymorphism, Single Nucleotide

Share to Receptor, Angiotensin, Type 2

Source

Open in PubMed Open full text

Identifiers

PMID: 42006151
DOI: 10.1155/humu/9394808
PMCID: PMC13084195

Genes

AGTR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delving Into the Depths of AGTR2: In Silico Identification of Deleterious Nonsynonymous SNPs Associated With Cardiovascular Diseases.PMID 42006151Read ↗

Computational analyses prioritize and reveal the deleterious nsSNPs in human angiotensinogen gene.Semantic proximity Read ↗

In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection.Semantic proximity Read ↗

In-silico analysis reveals druggable single nucleotide polymorphisms in angiotensin 1 converting enzyme involved in the onset of blood pressure.Semantic proximity Read ↗

Comprehensive in-silico analysis of deleterious SNPs in APOC2 and APOA5 and their differential expression in cancer and cardiovascular diseases conditions.Semantic proximity Read ↗

Structure-Based Analysis of Single Nucleotide Variants in the Renin-Angiotensinogen Complex.Semantic proximity Read ↗

Revising angiotensinogen from phylogenetic and genetic variants perspectives.Semantic proximity Read ↗

Revising the M235T polymorphism position for the AGT gene and reporting a modifying variant in the Brazilian population with potential cardiac and neural impact.Semantic proximity Read ↗

Combined sequence and sequence-structure-based methods for analyzing RAAS gene SNPs: a computational approach.Semantic proximity Read ↗

Exploring AT2R and its Polymorphism in Different Diseases: An Approach to Develop AT2R as a Drug Target beyond Hypertension.Semantic proximity Read ↗

A systematic review of nonsynonymous single nucleotide polymorphisms in the renin-angiotensin-aldosterone system.Semantic proximity Read ↗

In silico Approach for Exploring the Role of AT1R Polymorphism on its Function, Structure and Drug InteractionsSemantic proximity Read ↗

Genetic variability of human angiotensin‐converting enzyme 2 (hACE2) among various ethnic populationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.