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Article

Comprehensive in-silico analysis of deleterious SNPs in APOC2 and APOA5 and their differential expression in cancer and cardiovascular diseases conditions.

Genomics - 1 Mar 2023

Deng Huiyin, Li Jiuyi, Shah Abid Ali, Ge Lite, Ouyang Wen

Abstract excerpt

Genetic variations in APOC2 and APOA5 genes involve activating lipoprotein lipase (LPL), responsible for the hydrolysis of triglycerides (TG) in blood and whose impaired functions affect the TG metabolism and are associated with metabolic diseases. In this study, we investigate the biological significance of genetic variations at the DNA sequence and structural level using various computational tools....

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PMID: 36690263
DOI: 10.1016/j.ygeno.2023.110567

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