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Article

In-silico analysis reveals druggable single nucleotide polymorphisms in angiotensin 1 converting enzyme involved in the onset of blood pressure.

BMC research notes - 20 Dec 2021

Udosen Brenda, Soremekun Opeyemi, Ekenna Chinwe, Idowu Omotuyi Olaposi, Chikowore Tinashe, Nashiru Oyekanmi, Fatumo Segun

Abstract excerpt

OBJECTIVE: The Angiotensin 1 converting enzyme (ACE1) gene plays a critical role in regulating blood pressure and thus, it has become a major therapeutic target of antihypertensives. Single nucleotide polymorphisms (SNPs) occurring within a gene most especially at the functional segment of the genes alter the structure-function relationship of that gene. RESULTS: Our study revealed that five nsSNPs of the ACE1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34930451
DOI: 10.1186/s13104-021-05879-z
PMCID: PMC8686250

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