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Article

Causal effects of oxidative stress on hypertension: insights integrating multi-omics and colocalization analyses.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Aug 2026

Zhang Yue, Meng Jinyang, Yan Yucheng, Tang Hong, Zhong Dongling, Li Yuxi, Xue Peiwen, Zhang Anren, Jin Rongjiang, Li Juan

Abstract excerpt

BACKGROUND AND AIM: Oxidative stress (OS) plays a role in hypertension development, but the underlying genetic mechanisms are not completely understood. This study aimed to investigate the association between OS-related genes and hypertension by performing an integrative multi-omics analysis using summary-data-based Mendelian randomization (SMR) and colocalization approaches. METHODS AND RESULTS: We obtained...

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Topics

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Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension

Share to Mendelian Randomization Analysis

Share to Multiomics

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Share to Quantitative Trait Loci

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Source

Identifiers

PMID: 42002509
DOI: 10.1016/j.numecd.2026.104710

Genes

CYP19A1
PRDX2
SLC25A13
SUMF1
ADH5
CLN6
CLN8
GFPT1
PDGFB
S100A9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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