Article
MR1 encompasses at least six allele groups with coding region alterations.
HLA - 1 Dec 2021
Rozemuller Erik, Eckle Sidonia Barbara Guiomar, McLaughlin Ian, Penning Maarten, Mulder Wietse, de Bruin Helma, van Wageningen Sake
Abstract excerpt
Unlike classical HLA class I genes, MR1 is assumed to have limited polymorphic positions. We developed a MR1 specific PCR assay and sequenced 56 DNA samples from cells with a diverse set of HLA genotypes. In this relatively small panel we found six allele groups encoding for different MR1 proteins. The two most frequent allele groups found in this panel had a frequency of 71% (MR1*01) and 25% (MR1*02),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.