Article
The genetic landscape of gliomas arising after therapeutic radiation.
Acta neuropathologica - 1 Jan 2019
López Giselle Y, Van Ziffle Jessica, Onodera Courtney, Grenert James P, Yeh Iwei, Bastian Boris C, Clarke Jennifer, Oberheim Bush Nancy Ann, Taylor Jennie, Chang Susan, Butowski Nicholas, Banerjee Anuradha, Mueller Sabine, Kline Cassie, Torkildson Joseph, Samuel David, Siongco Aleli, Raffel Corey, Gupta Nalin, Kunwar Sandeep, Mummaneni Praveen, Aghi Manish, Theodosopoulos Philip, Berger Mitchel, Phillips Joanna J, Pekmezci Melike, Tihan Tarik, Bollen Andrew W, Perry Arie, Solomon David A
Abstract excerpt
Radiotherapy improves survival for common childhood cancers such as medulloblastoma, leukemia, and germ cell tumors. Unfortunately, long-term survivors suffer sequelae that can include secondary neoplasia. Gliomas are common secondary neoplasms after cranial or craniospinal radiation, most often manifesting as high-grade astrocytomas with poor clinical outcomes. Here, we performed genetic profiling on a cohort of...
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