Article
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas.
Nature communications - 4 Aug 2017
Agnihotri Sameer, Suppiah Suganth, Tonge Peter D, Jalali Shahrzad, Danesh Arnavaz, Bruce Jeffery P, Mamatjan Yasin, Klironomos George, Gonen Lior, Au Karolyn, Mansouri Sheila, Karimi Sharin, Sahm Felix, von Deimling Andreas, Taylor Michael D, Laperriere Normand J, Pugh Trevor J, Aldape Kenneth D, Zadeh Gelareh
Abstract excerpt
Cranial radiotherapy improves survival of the most common childhood cancers, including brain tumors and leukemia. Unfortunately, long-term survivors are faced with consequences of secondary neoplasia, including radiation-induced meningiomas (RIMs). We characterized 31 RIMs with exome/NF2 intronic sequencing, RNA sequencing and methylation profiling, and found NF2 gene rearrangements in 12/31 of RIMs, an...
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