Reduced ROS-associated prophage induction in a lepA mutant contributes to increased fluoroquinolone persistence in Salmonella Typhimurium.

Abstract excerpt

Bacterial persister cells are known to survive antibiotic treatment in the absence of typical resistance mechanisms. Persisters do not grow in the presence of antibiotics but can resume growth when antibiotic treatment is ceased, persisters are therefore often associated with chronic infections and treatment failure. In previous studies, it was shown that a lepA deletion strain of Escherichia coli was more...

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• Ciprofloxacin
• Fluoroquinolones
• Microbial Sensitivity Tests
• Oxidative Stress
• Prophages