Examining Genetic Variants Associated with FOXP1 Syndrome through Molecular Dynamics of Its DNA-Binding Domain and Self-Organizing Maps.

Abstract excerpt

Genetic mutations in the transcription factor FOXP1 (forkhead box protein P1) cause an autosomal dominant neurodevelopmental disorder called FOXP1 syndrome. To understand the structural impact of pathogenic variants associated with FOXP1 syndrome, we investigated the conformational changes resulting from six distinct missense variants in FOXP1 by combining molecular dynamics simulations, molecular docking, and...

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• Share to DNA
• Share to Forkhead Transcription Factors