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Article

Genomic diversity analysis enables development of pan-Dengue Toehold RNA sensors.

PLoS neglected tropical diseases - 1 Apr 2026

Nandakumar Anirudh, Mishra Deeksha, Shendre Akshay, Mendonca Edrea, Nagendra Soujanya, Gulyani Akash, Ramesh Arati

Abstract excerpt

The Dengue virus (DENV) like many other RNA viruses exhibits high genome sequence diversity. This poses a challenge to nucleic acid-based diagnostics, rendering them inefficient at detecting the diverse DENV strains circulating in a population. In this study, we address this challenge by developing a Toehold sensor assay that despite significant genomic diversity is able to detect ~99.4% of all strains of DENV....

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Identifiers

PMID: 41990017
DOI: 10.1371/journal.pntd.0014173
PMCID: PMC13086312

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