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Toehold switch plus signal amplification enables rapid detection

29 Aug 2023

Abstract excerpt

Recent world events have led to an increased interest in developing rapid and inexpensive clinical diagnostic platforms for viral detection. Here, the development of a cell-free toehold switch-based biosensor, which does not require upstream amplification of target RNA, is described for the detection of RNA viruses. Toehold switches were designed to avoid interfering secondary structure in the viral RNA binding...

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PMID: 37641181
DOI: 10.1002/biot.202200607

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