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Genomic diversity analysis enables development of pan-Dengue Toehold RNA sensors

2025-08-24

Abstract excerpt

<h4>ABSTRACT</h4> The Dengue virus (DENV) like many other RNA viruses exhibits high genome sequence diversity. This poses a challenge to nucleic acid-based diagnostics, rendering them inefficient at detecting the diverse DENV strains circulating in a population. In this study, we address this challenge by developing a Toehold sensor assay that despite significant genomic diversity is able to detect ∼99.4% of all...

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Literature Corpus work
c90f5df4-5efd-5a31-b0cb-5b9c1bc88232
DOI
10.1101/2025.08.23.671906
Open publication

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Genomic diversity analysis enables development of pan-Dengue Toehold RNA sensorsDOI 10.1101/2025.08.23.671906
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