Article
Exploring the Diversity and Function of the SPFH-Domain Containing Proteins in Pseudomonas aeruginosa.
Environmental microbiology reports - 1 Apr 2026
García-Maldonado Víctor Manuel, Rodríguez-Rangel Claudia, Georgellis Dimitris, Alvarez Adrián F
Abstract excerpt
The SPFH-domain containing proteins are widely conserved membrane-associated factors proposed to organise membrane microdomains and thereby regulate key cellular processes. In Pseudomonas aeruginosa PA14, we identified nine such proteins (HflK, HflC and PaFlo3-PaFlo9) that display remarkable sequence divergence, genomic variability and limited phylogenetic conservation. Functional analyses of single and multiple...
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