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Article

The FleQ-FleN circuit balances flagellar number against fitness in Pseudomonas aeruginosa.

mBio - 9 Sept 2026

Migueles-Lozano Anali, Asp Merrill, Rocha Sofia T, Li Jiaqi, Fanouraki Georgia, Sun Aden D, Zhang Lichun, Waldbauer Jacob R, Hong Jiarong, Shrivastava Abhishek, Yan Jing, Mukherjee Sampriti

Abstract excerpt

Evolutionary constraints governing flagellar number in bacterial pathogens remain poorly understood. While related Pseudomonas species are hyperflagellated, Pseudomonas aeruginosa maintains strict monoflagellation through the FleQ-FleN regulatory circuit. Here, we demonstrate that FleN dosage is essential for maintaining monoflagellation and fitness. Confirming earlier reports, wild-type P. aeruginosa displayed...

Read the complete abstract on PubMed

Topics

Pseudomonas aeruginosa
Flagella
Bacterial Proteins
Gene Expression Regulation, Bacterial
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Virulence

Genetic Fitness

Mutation

Trans-Activators

Source

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Identifiers

PMID: 42554464
DOI: 10.1128/mbio.00360-26
PMCID: PMC13556257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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