Article

Regulatory Plasticity and Metabolic Trade-offs Drive Adaptive Evolution of Alternative Flagellar Configurations in <i>Pseudomonas aeruginosa</i>

2025-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Evolutionary constraints governing flagellar number in bacterial pathogens remain poorly understood. While related Pseudomonas species are hyperflagellated, P. aeruginosa maintains strict monoflagellation through the FleQ-FleN regulatory circuit. Here, we demonstrate that FleN dosage is essential for maintaining monoflagellation and bacterial fitness. Wild-type P. aeruginosa consistently disp...

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Literature Corpus work: 38fe3f44-1644-52fd-943a-14d31f55774b
DOI: 10.1101/2025.07.29.667523

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