Article
A divergent Pseudomonas aeruginosa palmitoyltransferase essential for cystic fibrosis-specific lipid A.
Molecular microbiology - 1 Jan 2014
Thaipisuttikul Iyarit, Hittle Lauren E, Chandra Ramesh, Zangari Daniel, Dixon Charneal L, Garrett Teresa A, Rasko David A, Dasgupta Nandini, Moskowitz Samuel M, Malmström Lars, Goodlett David R, Miller Samuel I, Bishop Russell E, Ernst Robert K
Abstract excerpt
Strains of Pseudomonas aeruginosa (PA) isolated from the airways of cystic fibrosis patients constitutively add palmitate to lipid A, the membrane anchor of lipopolysaccharide. The PhoPQ regulated enzyme PagP is responsible for the transfer of palmitate from outer membrane phospholipids to lipid A. This enzyme had previously been identified in many pathogenic Gram-negative bacteria, but in PA had remained...
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