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Integrating network toxicology, machine learning, gut microbiome analysis, and structural validation to reveal the molecular mechanism linking PFOA and PFOS exposure to age-related macular degeneration

2026-01-29

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<title>Abstract</title> <p>Purpose Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are two ubiquitous persistent organic pollutants. Currently, little is known about the potential mechanisms of PFOA and PFOS in ophthalmic diseases. This study systematically investigates the effects of PFOA and PFOS exposure on age-related macular degeneration (AMD), aiming to identify potential targets and...

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Literature Corpus work
6dec9b9e-0d03-558e-96cb-bbd44ed12716
DOI
10.21203/rs.3.rs-8563077/v1
Open publication

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Integrating network toxicology, machine learning, gut microbiome analysis, and structural validation to reveal the molecular mechanism linking PFOA and PFOS exposure to age-related macular degenerationDOI 10.21203/rs.3.rs-8563077/v1
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