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Article

Association of TP53 polymorphic variants rs1042522 and rs1642785 with susceptibility and prognosis of acute lymphoblastic leukemia in a Brazilian Amazon population.

BMC medical genomics - 14 Apr 2026

Nogueira Glenda Menezes, Gonçalves Luca Gabriel Marques, Pereira-Ribeiro Thaís Lohana, Santos Larissa Silva, Magalhães-Gama Fábio, Araújo Nilberto Dias, Malheiro Adriana, Tarragô Andréa Monteiro, Alves-Hanna Fabíola Silva, Costa Allyson Guimarães

Abstract excerpt

BACKGROUND: Tumor suppressor genes play a central role in cancer development, and inherited genetic variation may influence both disease susceptibility and clinical outcomes. This study aimed to investigate the frequency and prognostic relevance of TP53 polymorphic variants in patients with acute lymphoblastic leukemia (ALL) from an admixed population in the Brazilian Amazon. METHODS: A population-based...

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Identifiers

PMID: 41981649
DOI: 10.1186/s12920-026-02371-0
PMCID: PMC13191962

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TP53

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