Association between the TPMT*3C (rs1142345) Polymorphism and the Risk of Death in the Treatment of Acute Lymphoblastic Leukemia in Children from the Brazilian Amazon Region.

doi:10.3390/genes11101132

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Article

Association between the TPMT*3C (rs1142345) Polymorphism and the Risk of Death in the Treatment of Acute Lymphoblastic Leukemia in Children from the Brazilian Amazon Region.

Genes - 25 Sept 2020

Cardoso de Carvalho Darlen, Pereira Colares Leitão Luciana, Mello Junior Fernando Augusto Rodrigues, Vieira Wanderley Alayde, Souza Tatiane Piedade de, Borges Andrade de Sá Roberta, Cohen-Paes Amanda, Rodrigues Fernandes Marianne, Santos Sidney, Salim Khayat André, Pimentel de Assumpção Paulo, Pereira Carneiro Dos Santos Ney

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the leading cause of death from pediatric cancer worldwide. However, marked ethnic disparities are found in the treatment of childhood ALL with less effective results and higher mortality rates being obtained in populations with a high level of Native American ancestry. Genetic variations of the patient can affect resistance to ALL chemotherapy and potentially play an...

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PMID: 32992962
DOI: 10.3390/genes11101132
PMCID: PMC7601477

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