Multilocus association of genetic variants in MLL, CREBBP, EP300, and TOP2A with childhood acute lymphoblastic leukemia in Hispanics from Texas.

doi:10.1158/1055-9965.EPI-11-0059

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Article

Multilocus association of genetic variants in MLL, CREBBP, EP300, and TOP2A with childhood acute lymphoblastic leukemia in Hispanics from Texas.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2011

Piwkham Duangjai, Gelfond Jonathan A L, Rerkamnuaychoke Budsaba, Pakakasama Samart, Rebel Vivienne I, Pollock Brad H, Winick Naomi J, Collier Anderson B, Tomlinson Gail E, Beuten Joke

Abstract excerpt

BACKGROUND: Hispanic children have both a higher incidence and a poorer outcome in acute lymphoblastic leukemia (ALL). Moreover, a higher incidence for therapy-related acute myeloid leukemia with 11q23 translocations after treatment with topoisomerase II (topo II) inhibitors has been observed in Hispanic children with ALL. We sought to determine the potential role of genetic variants within the topoisomerase IIα...

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PMID: 21493871
DOI: 10.1158/1055-9965.EPI-11-0059

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CREBBP
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