Article
CXCL12 and TP53 genetic polymorphisms as markers of susceptibility in a Brazilian children population with acute lymphoblastic leukemia (ALL).
Molecular biology reports - 1 Jul 2013
de Lourdes Perim Aparecida, Guembarovski Roberta Losi, Oda Julie Massayo Maeda, Lopes Leandra Fiori, Ariza Carolina Batista, Amarante Marla Karine, Fungaro Maria Helena Pelegrinelli, de Oliveira Karen Brajão, Watanabe Maria Angelica Ehara
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) genes may contribute to susceptibility to childhood ALL because they affect some important processes, such as metastasis re...
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