Article
Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity.
Nature - 1 Jun 2026
Nicola Pantelis A, Lawson Andrew R J, Tidd Alexandra, Imbert Juliette, Ishida Yoshihiro, Wylie Luke A, Scott Paul A, Roberts Kenny, Harvey Luke M R, Lensing Stefanie V, Cheng Wei, Abascal Federico, Leongamornlert Daniel, Hooks Yvette, Mayho Matthew, Müller-Sienerth Nicole, Widaa Sara, Mincarelli Laura, Illing James, Peci Flavia, Ng Bee Ling, Jarman Georgeina L, Russell Andrew J C, Mahbubani Krishnaa T A, Saeb-Parsy Kourosh, Paterson Anna L, Chatterjee Krishna, Rahbari Raheleh, Bayraktar Omer Ali, Stratton Michael R, Campbell Peter J, Tadross John A, Schoenmakers Nadia, Martincorena Iñigo
Abstract excerpt
Our immune system contains multiple checkpoints to prevent the activation of self-reactive lymphocytes. How some lymphocytes escape these constraints to cause autoimmune disease remains poorly understood. A long-standing hypothesis posits that somatic mutations in immune regulatory genes may enable self-reactive lymphocytes to bypass tolerance checkpoints1-3, but testing this has been challenging owing to...
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