Article
Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2017
Miosge Lisa A, Sontani Yovina, Chuah Aaron, Horikawa Keisuke, Russell Tiffany A, Mei Yan, Wagle Mayura V, Howard Debbie R, Enders Anselm, Tscharke David C, Goodnow Christopher C, Parish Ian A
Abstract excerpt
T-cell immunity requires extremely rapid clonal proliferation of rare, antigen-specific T lymphocytes to form effector cells. Here we identify a critical role for ETAA1 in this process by surveying random germ line mutations in mice using exome sequencing and bioinformatic annotation to prioritize mutations in genes of unknown function with potential effects on the immune system, followed by breeding to...
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