Article
Thyroid MALT lymphoma: self-harm to gain potential T-cell help.
Leukemia - 1 Dec 2021
Wu Fangtian, Watanabe Natsuko, Tzioni Maria-Myrsini, Akarca Ayse, Zhang Chunye, Li Yan, Chen Zi, Cucco Francesco, Carmell Natasha, Noh Jaeduk Yoshimura, Ito Koichi, Dobson Rachel, Moody Sarah, Yao Wenqing, Zhang Wenyan, Liu Weiping, Liu Hongxiang, Okosun Jessica, Chott Andreas, Bi Yingwen, Chuang Shih-Sung, Raderer Markus, Li Jian-Yong, Marafioti Teresa, Du Ming-Qing
Abstract excerpt
The development of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is driven by chronic inflammatory responses and acquired genetic changes. To investigate its genetic bases, we performed targeted sequencing of 93 genes in 131 MALT lymphomas including 76 from the thyroid. We found frequent deleterious mutations of TET2 (86%), CD274 (53%), TNFRSF14 (53%), and TNFAIP3 (30%) in thyroid...
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