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Article

Unraveling the Complexity of Celiac Disease: A Narrative Review of Its Multisystem Nature.

Medicina (Kaunas, Lithuania) - 6 Jan 2026

Rogalidou Maria, Christodoulou Dimitrios

Abstract excerpt

Celiac disease is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically susceptible individuals, primarily those carrying HLA-DQ2 or HLA-DQ8 and, in rare cases, HLA DQ7 alleles. Although traditionally regarded as a gastrointestinal condition, celiac disease is now recognized as a multisystem disorder with a wide range of clinical presentations. It has been described as a "clinical...

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Identifiers

PMID: 41597406
DOI: 10.3390/medicina62010120
PMCID: PMC12843487

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